Pharmacology of inhibitory amino acid transporters (GABA transporters and glycine transporters)
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چکیده
منابع مشابه
Cationic Amino Acid Transporters
We have identified the third member of a family of cationic amino acid transporters in lipopolysaccharidestimulated murine macrophages. The deduced amino acid sequence of this transporter is the same as MCAT-2 (mouse cationic amino acid transporter-Z), the low affinity transporter expressed in hepatocytes, except for a stretch of 41 amino acids that connects the eighth and ninth membrane-spanni...
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• The heavy subunits (molecular mass of ~90 and ~80 kDa for rBAT and 4F2hc, respectively) are type II membrane N-glycoproteins with a single transmembrane domain, an intracellular NH2 terminus, and an extracellular COOH terminus significantly homologous to insect and bacterial glucosidases (FIGURE 1). Recently, X-ray diffraction of the extracellular domain of human 4F2hc revealed a three-dimens...
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The regulation of neurotransmitter transporters is a central aspect of their physiology. Recent studies that focused on syntaxin-1 transporter interactions led to the postulation that syntaxin-1 is somehow implicated in protein trafficking. Because syntaxin-1 is involved in the exocytosis of neurotransmitters and it interacts with glycine transporter 2 (GLYT2), we stimulated exocytosis in synap...
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Glycine, an important inhibitory neurotransmitter in the mammalian central nervous system (CNS), has been shown to modulate peripheral immune cell responses. In that respect, glycine levels are increased in several neuroinflammatory disorders, such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). In this study, we show that glycine modulates macrophage effector functions impl...
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Amino acid (AA) transporters may act as sensors, as well as carriers, of tissue nutrient supplies. This review considers recent advances in our understanding of the AA-sensing functions of AA transporters in both epithelial and nonepithelial cells. These transporters mediate AA exchanges between extracellular and intracellular fluid compartments, delivering substrates to intracellular AA sensor...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2006
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.127.279